Photosynthesis‐Inspired NIR‐Triggered Fe₃O₄@MoS₂ Core–Shell Nanozyme for Promoting MRSA‐Infected Diabetic Wound Healing
Jiamu Xiao, Xueqin An, Fei Tang, Xu Dai, Song Zhang, Xiaolong Zhu, Jian Shen, Jiang Yuan, Donglin Gan, Mingqian Wang
Abstract
Abstract Bacterial infections can lead to severe medical complications, including major medical incidents and even death, posing a significant challenge in clinical trauma repair. Consequently, the development of new, efficient, and non‐resistant antimicrobial agents has become a priority for medical practitioners. In this study, a stepwise hydrothermal reaction strategy is utilized to prepare Fe 3 O 4 @MoS 2 core–shell nanoparticles (NPs) with photosynthesis‐like activity for the treatment of bacterial infections. The Fe 3 O 4 @MoS 2 NPs continuously catalyze the production of reactive oxygen species (ROS) from hydrogen peroxide through photosynthesis‐like reactions and convert light energy into heat with a photothermal efficiency of 30.30%. In addition, the photosynthetically generated ROS, combined with the iron‐induced cell death mechanism of the Fe 3 O 4 @MoS 2 NPs, confer them with exceptional and broad‐spectrum antibacterial properties, achieving antimicrobial activities of up to 98.62% for Staphylococcus aureus , 99.22% for Escherichia coli , and 98.55% for methicillin‐resistant Staphylococcus aureus . The composite exhibits good cell safety and hemocompatibility. Finally, a full‐thickness diabetic wound model validates the significant pro‐healing properties of Fe 3 O 4 @MoS 2 in chronic diabetic wounds. Overall, the design of photosynthesis‐inspired Fe 3 O 4 @MoS 2 presents new perspectives for developing efficient photothermal nano‐enzymatic compounds, offering a promising solution to the challenges of antimicrobial drug resistance and antibiotic misuse.