The Ribbon-Helix-Helix Domain Protein CdrS Regulates the Tubulin Homolog <i>ftsZ2</i> To Control Cell Division in Archaea
Cynthia L. Darnell, Jenny Z. Zheng, Sean Wilson, Ryan Bertoli, Alexandre W. Bisson‐Filho, Ethan C. Garner, Amy Schmid
Abstract
Healthy cell growth and division are critical for individual organism survival and species long-term viability. However, it remains unknown how cells of the domain Archaea maintain a healthy cell cycle. Understanding the archaeal cell cycle is of paramount evolutionary importance given that an archaeal cell was the host of the endosymbiotic event that gave rise to eukaryotes. Here, we identify and characterize novel molecular players needed for regulating cell division in archaea. These molecules dictate the timing of cell septation but are dispensable for growth between divisions. Timing is accomplished through transcriptional control of the cell division ring. Our results shed light on mechanisms underlying the archaeal cell cycle, which has thus far remained elusive.