Synthesis of Mo–Pt/CeO <sub>2</sub> Dual Single‐Atom Nanozyme for Multifunctional Biochemical Detection Applications
Litao Ge, Yujia Chen, Baokang Geng, Xiang Chu, Ruize Jiang, Xiao Wang, Xinxin Qin, Wei Li, Shuyan Song
Abstract
Abstract Elaborated structural modulation of Pt‐based artificial nanozymes can efficiently improve their catalytic activity and expand their applications in clinical diagnosis and biochemical sensing. Herein, a highly efficient dual‐site peroxidase mimic composed of highly dispersed Pt and Mo atoms is reported. The obtained Mo–Pt/CeO 2 exhibits exceptional peroxidase‐like catalytic activity, with a V max as high as 34.16 × 10 −8 m s −1 , which is 37.5 times higher than that of the single‐site counterpart. Mechanism studies suggest that the Mo atoms can not only serve as adsorption and activation sites for the H 2 O 2 substrate but also regulate the charge density of Pt centers to promote the generation ability of •OH. As a result, the synergistic effect between the dual active sites significantly improves the catalytic efficiency. Significantly, the application of the Mo–Pt/CeO 2 catalyst's excellent peroxidase‐like activity is extended to various biochemical detection applications, including the trace detection of glucose and cysteine, as well as the assessment of antioxidants' antioxidant capacity. This work reveals the great potential of rational design dual‐site active centers for constructing high‐performance artificial nanozymes.