Tuning the Biological Activity of RGD Peptides with Halotryptophans
Isabell Kemker, David Schröder, Rebecca C. Feiner, Kristian M. Müller, Antoine Marion, Norbert Sewald
Abstract
. Extensive molecular dynamics simulations were undertaken to elucidate NMR and high-performance liquid chromatography (HPLC) data for these late-stage diversified cyclic RGD peptides and to further characterize their conformational preferences.
Topics & Concepts
ChemistryMoietyIndole testSelectivityIntegrinCombinatorial chemistryCyclic peptideStereochemistryConjugated systemPeptideTryptophanBiochemistryAmino acidOrganic chemistryReceptorPolymerCatalysisChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies ResearchClick Chemistry and Applications