Carnosic acid ameliorated Aβ-mediated (amyloid-β peptide) toxicity, cholinergic dysfunction and mitochondrial defect in <i>Caenorhabditis elegans</i> of Alzheimer's Model
Yun Chen, Yun Chen, Yarong Wang, Qiao Qin, Yali Zhang, Lingling Xie, Jie Xiao, Yong Cao, Zuanxian Su, Yunjiao Chen, Yunjiao Chen
Abstract
Carnosic acid reduced Aβ deposition and Aβ-mediated neurotoxicity, and ameliorated cholinergic dysfunction and mitochondrial disorders in the C. elegans model of Alzheimer's disease.
Topics & Concepts
Caenorhabditis elegansCholinergicNeuroprotectionOxidative stressCarnosic acidNeurodegenerationAmyloid precursor proteinToxicityProteostasisAcetylcholinesteraseMitochondrionBiologyAmyloid (mycology)Cell biologyPharmacologyCholinergic neuronNeurotoxicityChemistryAlzheimer's diseaseBiochemistryAntioxidantNeuroscienceInternal medicineMedicineGeneDiseaseOrganic chemistryBotanyEnzymeCholinesterase and Neurodegenerative DiseasesBiochemical effects in animalsAlzheimer's disease research and treatments