Iron-Catalyzed Ring Expansion of Cyclobutanols for the Synthesis of 1-Pyrrolines by Using MsONH<sub>3</sub>OTf
Daijiao Zhuang, Tharcisse Gatera, Zhenyu An, Rulong Yan
Abstract
The synthesis of 1-pyrrolines from cyclobutanol derivatives and an aminating reagent (MsONH3OTf) has been developed. This one-pot procedure achieves C–N bond/C═N bond formation via ring expansion. A series of 1-pyrroline derivatives are synthesized in moderate to good yields under mild conditions.
Topics & Concepts
ChemistryReagentRing (chemistry)CatalysisMedicinal chemistryPyrrolineCombinatorial chemistryStereochemistryOrganic chemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisAsymmetric Synthesis and Catalysis