WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice.
Jaeoh Park, Jeong Sik Kim, Ji Hae Nahm, Sang Kyum Kim, Da-Hye Lee, Dae‐Sik Lim
Abstract
system resulted in iCCA development through hyperactivation of YAP/TAZ. These findings suggest that WWC1 and NF2 cooperate to promote suppression of cholangiocarcinoma development by inhibiting the oncogenic activity of YAP/TAZ via LATS1/2.
Topics & Concepts
Hippo signaling pathwayCarcinogenesisCancer researchMerlin (protein)BiologyProgenitor cellSuppressorYAP1Liver cancerTranscription factorCell biologyIntrahepatic CholangiocarcinomaSignal transductionCancerStem cellHepatocellular carcinomaInternal medicineGeneticsGeneMedicineHippo pathway signaling and YAP/TAZLipid metabolism and biosynthesisUbiquitin and proteasome pathways