An allosteric redox switch in domain V of β2-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition
Suresh Kumar, Mathivanan Chinnaraj, William Planer, Xiaobing Zuo, Paolo Macor, Francesco Tedesco, Nicola Pozzi
Abstract
GPI's physiological functions in a redox-dependent manner. We propose that in APS patients with anti-DI antibodies, selective rupture of the C288-C326 disulfide bond may be a valid strategy to lower the pathogenic potential of aPL.
Topics & Concepts
Allosteric regulationAutoantibodyChemistryDomain (mathematical analysis)GlycoproteinRedoxBiophysicsCell biologyBiochemistryAntibodyReceptorBiologyImmunologyMathematicsMathematical analysisOrganic chemistryMonoclonal and Polyclonal Antibodies ResearchSystemic Lupus Erythematosus ResearchAtherosclerosis and Cardiovascular Diseases