Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity
Mohamed T. M. Nemr, Amr Sonousi, Adel A. Marzouk
Topics & Concepts
TopoisomeraseChemistryEtoposideApoptosisDocking (animal)Cell cycleIC50DoxorubicinCell growthCell cultureGrowth inhibitionCell cycle checkpointPharmacologyCancer researchBiochemistryEnzymeIn vitroBiologyInternal medicineChemotherapyMedicineNursingGeneticsCancer therapeutics and mechanismsSynthesis and biological activitySynthesis and Biological Evaluation