Pharmacological inhibition of MYC to mitigate chemoresistance in preclinical models of squamous cell carcinoma
Shuo Liu, Zhen Qin, Yaqing Mao, Ning Wang, Wenbo Zhang, Yujia Wang, Yiwen Chen, Lingfei Jia, Xin Peng
Abstract
Our findings suggested that targeting MYC might eliminate CSCs, prevent metastasis, and activate antitumor immunity to overcome cisplatin resistance in HNSCC.
Topics & Concepts
CisplatinCancer researchHead and neck squamous-cell carcinomaMetastasisCancer stem cellCD44MedicineCancerCellHead and neck cancerBiologyChemotherapyInternal medicineGeneticsinterferon and immune responsesUbiquitin and proteasome pathwaysCancer-related molecular mechanisms research