Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
Ida Monrad, Signe Risgaard Sahlertz, Stine Sofie Frank Nielsen, Louise Ørnskov Pedersen, Mikkel Steen Petersen, Carl M. Kobel, Irene Harder Tarpgaard, Merete Storgaard, Klaus Leth Mortensen, Mariane Høgsbjerg Schleimann, Martin Tolstrup, Line K. Vibholm
Abstract
We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.
Topics & Concepts
MedicineCoronavirusRespiratory systemVirologyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ImmunologyDiseaseInfectious disease (medical specialty)Internal medicineSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing