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Discovery of novel hydroxyamidine based indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) dual inhibitors

Ji Zhou, Lizhen Yu, Yali Fan, Ci-Hao Guo, Xiaomei Lv, Zhiyin Zhou, Huidan Huang, Dong‐Dong Miao, Shengpeng Zhang, Xinyu Li, Pingping Zhao, Xiaoping Liu, Weihua Hu, Chao Zhang

2022European Journal of Medicinal Chemistry21 citationsDOIOpen Access PDF

Topics & Concepts

Indoleamine 2,3-dioxygenaseChemistryKynurenineThioredoxin reductaseIn vivoApoptosisPharmacologyCancer researchThioredoxinIC50BiochemistryIn vitroEnzymeBiologyTryptophanBiotechnologyAmino acidTryptophan and brain disordersPharmacological Receptor Mechanisms and EffectsImmune cells in cancer
Discovery of novel hydroxyamidine based indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) dual inhibitors | Litcius