Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur
Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W. Guddat, Gengfu Xiao, Leike Zhang, Haitao Yang, Zihe Rao
Topics & Concepts
ProteaseChemistryDrugProtease inhibitor (pharmacology)Mechanism of actionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Covalent bondBiophysicsViral replicationCoronavirus disease 2019 (COVID-19)StereochemistryBiochemistryEnzymePharmacologyVirusVirologyBiologyIn vitroMedicineAntiretroviral therapyOrganic chemistryPathologyDiseaseInfectious disease (medical specialty)Viral loadSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesComputational Drug Discovery Methods