Design and synthesis of copper(<scp>ii</scp>) and nickel(<scp>ii</scp>) complexes as potential inhibitors against SARS-CoV-2 viral RNA binding protein and Omicron RBD protein
Reyaz Ahmad, Mukesh Choudhary
Abstract
Two bis-Schiff base metal( ii ) complexes [Cu(L) 2 ](1) and [Ni(L) 2 ](2) were designed and synthesized as potential inhibitors for the development of new anti-SARS-CoV-2 Omicron and anti-HIV drugs.
Topics & Concepts
ChemistryCopperNickelRNACoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)RNA-binding proteinBiochemistryOrganic chemistryGenePathologyMedicineDiseaseInfectious disease (medical specialty)Computational Drug Discovery MethodsMetal complexes synthesis and propertiesSynthesis and biological activity