Methanol as a C1 Source for the Synthesis of 1,3‐Polyheterocyclic Systems
L. Molteni, Egle M. Beccalli, Laura Castoldi, Gianluigi Broggini, Camilla Loro
Abstract
Abstract A very attractive approach toward 1,3‐polyheterocyclic systems was provided exploiting the copper‐catalyzed reaction of aminoalcohols and diaminoalkanes, in oxidative conditions and in the presence of methanol. The synthetic pathway showed the involvement of methanol both as solvent and as a reagent, making the procedure particularly efficient and sustainable for the synthesis of five‐, six‐, and seven‐membered polyheterocyclic rings.
Topics & Concepts
ChemistryMethanolReagentCombinatorial chemistrySolventCatalysisOrganic chemistryAsymmetric Hydrogenation and CatalysisCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods