Litcius/Paper detail

<i>N</i>-Trifluoromethyl Amines and Azoles: An Underexplored Functional Group in the Medicinal Chemist’s Toolbox

Stefan Schießer, Hanna Chepliaka, Johanna Kollback, Thibaut Quennesson, Werngard Czechtizky, Rhona J. Cox

2020Journal of Medicinal Chemistry105 citationsDOI

Abstract

-trifluoromethyl azoles are valuable substructures to be considered in medicinal chemistry.

Topics & Concepts

TrifluoromethylChemistryLipophilicityCombinatorial chemistryStereochemistryOrganic chemistryMedicinal chemistryAlkylFluorine in Organic ChemistrySynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms