IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs
Brendan M Barton, Francheska Son, Akanksha Verma, Saswat Kumar Bal, Qianzi Tang, Rui Wang, Katharine Umphred-Wilson, Rehan Khan, Josephine Trichka, Han Dong, Claudia Lentucci, Xi Chen, Yinghua Chen, Yuning Hong, Cihangir Duy, Olivier Elemento, Ari Melnick, Jin Cao, Xi Chen, Laurie H. Glimcher, Stanley Adoro
Topics & Concepts
XBP1HaematopoiesisStem cellProgenitor cellBiologyMyeloid leukemiaCD34Cancer researchMyeloidCell biologyGeneGeneticsRNA splicingRNAImmune Cell Function and InteractionAcute Lymphoblastic Leukemia researchAutophagy in Disease and Therapy