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IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs

Brendan M Barton, Francheska Son, Akanksha Verma, Saswat Kumar Bal, Qianzi Tang, Rui Wang, Katharine Umphred-Wilson, Rehan Khan, Josephine Trichka, Han Dong, Claudia Lentucci, Xi Chen, Yinghua Chen, Yuning Hong, Cihangir Duy, Olivier Elemento, Ari Melnick, Jin Cao, Xi Chen, Laurie H. Glimcher, Stanley Adoro

2025Nature Immunology15 citationsDOI

Topics & Concepts

XBP1HaematopoiesisStem cellProgenitor cellBiologyMyeloid leukemiaCD34Cancer researchMyeloidCell biologyGeneGeneticsRNA splicingRNAImmune Cell Function and InteractionAcute Lymphoblastic Leukemia researchAutophagy in Disease and Therapy
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs | Litcius