Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance
Kelsey Temprine, Nathaniel R. Campbell, Ting Huang, Erin M. Langdon, Theresa Simon-Vermot, Krisha Mehta, Averill Clapp, Mollie E. Chipman, Richard M. White
Abstract
encountering cell stress and nutrient deprivation can up-regulate and activate DinB/pol IV, the bacterial ortholog of Polκ, to induce mutagenesis that enables stress tolerance or escape. However, we found that the increased expression of Polκ was not excessively mutagenic, indicating that noncatalytic or other functions of Polκ could mediate its role in stress responses in mammalian cells. Repressing the expression or nuclear localization of Polκ might prevent drug resistance in some cancer cells.
Topics & Concepts
DNA polymeraseBiologyDNA damageCell biologyDNA repairDNA replicationKinasePolymeraseCancer researchMolecular biologyGeneticsDNADNA Repair MechanismsGenetic factors in colorectal cancerCancer-related Molecular Pathways