Regional and interindividual relationships between cerebral perfusion and oxygen metabolism
Otto Mølby Henriksen, Albert Gjedde, Kim Vang, Ian Law, Joel Aanerud, Egill Rostrup
Abstract
Using quantitative PET-measurements in healthy human subjects, we confirmed a regional association of CBF and CMRO 2 , but did not find an association of these values across subjects. This suggests that subjects have an individual coupling between perfusion and metabolism and shows that absolute perfusion measurements does not serve as a surrogate measure of individual measures of oxygen metabolism. The analysis further showed smaller, but significant regional differences of oxygen extraction fraction at rest.
Topics & Concepts
Oxygen metabolismPerfusionMetabolismCerebral blood flowOxygenInternal medicineNeuroscienceCardiologyMedicineChemistryBiologyOrganic chemistryAdvanced MRI Techniques and ApplicationsTraumatic Brain Injury and Neurovascular DisturbancesFunctional Brain Connectivity Studies