Curcumin enhances the membrane trafficking of the sodium iodide symporter and augments radioiodine uptake in dedifferentiated thyroid cancer cells <i>via</i> suppression of the PI3K-AKT signaling pathway
Li Zhang, Shichen Xu, Xian Cheng, Jing Wu, Xiaowen Wang, Liying Wu, Huixin Yu, Jiandong Bao
Abstract
the inhibition of the PI3K-AKT-mTOR signaling pathway. Our study demonstrates that curcumin could represent a promising adjunctive therapy for restoring iodide avidity and improve radioiodine therapeutic efficacy in patients with RAI-refractory thyroid carcinoma.
Topics & Concepts
Sodium-iodide symporterThyroid cancerSymporterCurcuminCancer researchPI3K/AKT/mTOR pathwayProtein kinase BChemistryThyroidEndocrinologyInternal medicineThyroid peroxidaseMedicineSignal transductionPharmacologyBiochemistryGeneTransporterThyroid Cancer Diagnosis and TreatmentS100 Proteins and AnnexinsBiomarkers in Disease Mechanisms