Stereoselective Synthesis of Spirooxindole Derivatives Using One-Pot Multicomponent Cycloaddition Reaction and Evaluation of Their Antiproliferative Efficacy
Rajat Ghosh, Jorge M. B. Vítor, Eduarda Mendes, Alexandra Paulo, Pratap Chandra Acharya
Abstract
produced selective cytotoxicity against leukemia, renal, colon, and prostate cancer cell lines at a 10 μM concentration. The G4 interaction studies further suggested that these spirooxindole derivatives were devoid of any activity as DNA G4 ligands.
Topics & Concepts
StereoselectivityIsatinChemistryCycloadditionSarcosinePyrrolidineAzomethine ylidePyrrolizidineCombinatorial chemistryStereochemistry1,3-Dipolar cycloadditionOrganic chemistryAmino acidBiochemistryCatalysisGlycineMulticomponent Synthesis of HeterocyclesChemical Synthesis and AnalysisSynthesis and Biological Evaluation