Ligand‐Enabled Gold‐Catalyzed Cyanation of Organohalides
Anil Kumar, Nandita Bhattacharya, Manoj V. Mane, Nitin T. Patil
Abstract
)-CN cross-coupling reaction by employing a ligand-enabled Au(I)/Au(III) redox catalysis. This transformation utilizes acetone cyanohydrin as a nucleophilic cyanide source to convert simple aryl and alkenyl iodides into the corresponding nitriles. Combined experimental and computational studies highlighted the crucial role of cationic silver salts in activating the stable (P,N)-AuCN complex towards the oxidative addition of aryl iodides to subsequently generate key aryl-Au(III) cyanide complexes.
Topics & Concepts
CyanationCyanideArylChemistryCatalysisCationic polymerizationLigand (biochemistry)NucleophileCombinatorial chemistryCyanohydrinReductive eliminationOrganic chemistryBiochemistryReceptorAlkylCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions