Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon
Lewis Caiger, Conar Sinton, Timothée Constantin, James J. Douglas, Nadeem S. Sheikh, Fabio Juliá, Daniele Leonori
Abstract
. This event delivers a phosphoranyl radical that re-generates the alkyl radical and provides the hydroxymethylated product.
Topics & Concepts
SynthonAlkylFormaldehydeChemistryHalogenOrganic chemistryCombinatorial chemistryPhotochemistryRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsVanadium and Halogenation Chemistry