Unexpected cyclization of <i>ortho</i>-nitrochalcones into 2-alkylideneindolin-3-ones
Nicolai A. Aksenov, Дмитрий А. Аксенов, Nikolai A. Arutiunov, Daria S. Aksenova, А. В. Аксенов, Michael Rubin
Abstract
-nitrochalcones is described. The featured transformation is a triggered Michael addition of the cyanide anion to the chalcone followed by a cascade cyclization mechanistically related to the Baeyer-Drewson reaction.
Topics & Concepts
AcetonitrilesChalconeMichael reactionChemistryCombinatorial chemistryCascadeCyanideTransformation (genetics)Medicinal chemistryStereochemistryOrganic chemistryChromatographyCatalysisBiochemistryAcetonitrileGeneQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationSynthesis and biological activity