A mitochondrion-targeted BODIPY-Ir(<scp>iii</scp>) conjugate as a photoinduced ROS generator for the oxidative destruction of triple-negative breast cancer cells
Liping Qiao, Jiangping Liu, Shi Kuang, Xinxing Liao, Jun‐Feng Kou, Liang‐Nian Ji, Hui Chao
Abstract
A mitochondria-targeted BODIPY-Ir(III) conjugate acted as a photoinduced ROS generator and exerted high oxidative lethality towards triple-negative breast cancer cells at an ultralow concentration under irradiation.
Topics & Concepts
BODIPYPhotodynamic therapyConjugateReactive oxygen speciesBiophysicsChemistryApoptosisCancer cellOxidative phosphorylationTriple-negative breast cancerCancer researchMitochondrionMaterials scienceCancerFluorescenceBiochemistryMedicineBiologyBreast cancerInternal medicinePhysicsMathematicsMathematical analysisOrganic chemistryQuantum mechanicsNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials