Synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines and isocoumarins enabled by multi-component reagents system (MCRS)
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
Abstract
The combining use of BnSCF 2 D, m CPBA and Tf 2 O serves as an efficient multi-component reagents system (MCRS) for the synthesis of 4-SCF 2 D-isocoumarins-1-imines/isocoumarins via intramolecular cyclization of 2-alkynylbenzamides/2-alkynylbenzoates.
Topics & Concepts
IsocoumarinsComponent (thermodynamics)ReagentChemistryCombinatorial chemistryOrganic chemistryCatalysisPhysicsThermodynamicsSynthesis and Biological ActivityChemical Reactions and IsotopesFluorine in Organic Chemistry