Vascular transplantation with dual-biofunctional ePTFE vascular grafts in a porcine model
Xing Zheng, Shu‐Ting Wu, Chen Zhao, Yating Bai, Dawei Jin, Meng Yin, Haifeng Liu, Yubo Fan
Abstract
. Since a large animal could relatively better mimic human physiology, we chose a porcine carotid artery replacement model in the current study. The results showed that the BVLD/REDV co-modified ePTFE vascular grafts had a satisfactory patency rate (66.7%) and a higher endothelial cell coverage ratio (70%) at 12 weeks after implantation. This may offer an opportunity to produce a multi-biofunctional ePTFE vascular graft, thereby yielding a potent product to meet the clinical needs.
Topics & Concepts
BivalirudinVascular graftTransplantationCarotid arteriesIn vivoBiomedical engineeringMedicineMaterials scienceSurgeryCardiologyBiologyBiotechnologyPercutaneous coronary interventionMyocardial infarctionElectrospun Nanofibers in Biomedical ApplicationsPolymer Surface Interaction StudiesInfectious Aortic and Vascular Conditions