<i>In vitro</i> and <i>in vivo</i> antitumor effects of lupeol-loaded galactosylated liposomes
Jun Zhang, Xixi Hu, Guohua Zheng, Hui Yao, Huali Liang
Abstract
targeting studies showed that Gal-NR-L exhibited liver-targeting effects on FVB mice. The pharmacodynamic study was performed by transfecting AKT and c-MET via the high-pressure tail vein of FVB mice. After Gal-lupeol-L administration, the liver index and liver weight of mice were less than those non-targeted group. The histopathological study showed that the lobular structure in the mice liver was clearer, the vacuoles were more obvious, and the cytoplasm was more abundant after Gal-lupeol-L administration. Also, the qRT-PCR study showed that AFP, GPC3, and EpCAM mRNA expression levels were significantly lower than those non-targeted lupeol-liposomes.
Topics & Concepts
LupeolLiposomeIn vivoChemistryBiophysicsMaterials scienceBiochemistryBiologyBiotechnologyNatural product bioactivities and synthesisNanoparticle-Based Drug DeliveryDrug Transport and Resistance Mechanisms