Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core–Shell Electrospun Membranes: A Proof of Concept
Martina Gruppuso, Benedetta Guagnini, Luigi Musciacchio, Francesca Bellemo, Gianluca Turco, Davide Porrelli
Abstract
. The biocompatibility of the released rifampicin was assessed too on murine fibroblasts, revealing no cytotoxic effects. Hence, the presented coaxial system should be further optimized to tune the drug release according to the antibacterial effectiveness.
Topics & Concepts
CoaxialMaterials scienceBiocompatibilityPolycaprolactoneMembraneAntibacterial activityChitosanSurface modificationChemical engineeringBiomedical engineeringComposite materialChemistryBiochemistryBacteriaPolymerBiologyMedicineElectrical engineeringEngineeringMetallurgyGeneticsElectrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative MedicineGraphene and Nanomaterials Applications