Direct trifluoromethylselenolations of electron-rich (hetero)aromatic rings with <i>N</i>-trifluoromethylselenolating saccharin
Guiya Gao, Ke-Yi Xie, Minghui Shi, Tao Gao, Zedong Wang, Zedong Wang, Congcong Zhang, Zhentao Wang, Zhentao Wang
Abstract
-Trifluoromethylselenosaccharin proves to be an efficient trifluoromethylselenolating reagent, enabling the direct trifluoromethylselenolation of various electron-rich aromatic and heteroaromatic rings under mild reaction conditions. It exhibits excellent chemoselectivity and excellent compatibility with various functional groups, making it suitable for late-stage trifluoromethylselenolation applications in complex natural product and drug synthesis.
Topics & Concepts
ReagentSaccharinElectrophileChemistryElectronCombinatorial chemistryOrganic chemistryMedicinal chemistryPhysicsCatalysisBiologyEndocrinologyQuantum mechanicsFluorine in Organic ChemistryInorganic Fluorides and Related Compounds