Litcius/Paper detail

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation

Yuqing Feng, Conglei Li, Jessica A. Stewart, Philip Barbulescu, Noé Seija Desivo, Alejandro Álvarez-Quilón, Rossanna C. Pezo, Madusha L. W. Perera, Katherine Chan, Amy H.Y. Tong, Rukshana Mohamad-Ramshan, Maribel Berrú, Diana Nakib, Gavin Li, Gholam Ali Kardar, James R. Carlyle, Jason Moffat, Daniel Durocher, Javier M. Di Noia, Ashok S. Bhagwat, Alberto Martin

2021Nature70 citationsDOIOpen Access PDF

Topics & Concepts

Somatic hypermutationCytidine deaminaseDNA glycosylaseUracil-DNA glycosylaseImmunoglobulin class switchingDNA repairMutagenesisDNA mismatch repairBase excision repairActivation-induced (cytidine) deaminaseMutationChemistryBiologyCell biologyCell cycle checkpointDNACell cycleGeneticsGeneB cellAntibodyDNA Repair MechanismsImmune Cell Function and InteractionT-cell and B-cell Immunology