Pharmacokinetics-based Chronotherapy
Danyi Lu, Zhigang Wang, Baojian Wu
Abstract
Dosing time-dependency of pharmacokinetics (or chronopharmacokinetics) has been long recognized. Studies in recent years have revealed that daily rhythmicity in expression of drug-metabolizing enzymes and transporters (DMETs) are key factors determining chronopharmacokinetics. In this article, we briefly summarize current knowledge with respect to circadian mechanisms of DMETs and discuss how rhythmic DMETs are translated to drug chronoeffects. More importantly, we present our perspectives on pharmacokinetics-based chronotherapy.
Topics & Concepts
Chronotherapy (sleep phase)PharmacokineticsCircadian rhythmDosingPharmacologyDrugMedicineTransporterIntensive care medicineInternal medicineBiologyBiochemistryGeneCircadian rhythm and melatoninDietary Effects on HealthPharmacogenetics and Drug Metabolism