Nephronectin promotes cardiac repair post myocardial infarction via activating EGFR/JAK2/STAT3 pathway
Yaping Zhang, Di Wang, Zhe Zhao, Liang Liu, Guofang Xia, Tianbao Ye, Yu Chen, Chuanshan Xu, Xian Jin, Chengxing Shen
Abstract
Background: ECM proteins are instrumental for angiogenesis, which plays momentous roles during development and repair in various organs, including post cardiac insult. After a screening based on an open access RNA-seq database, we identified Nephronectin (NPNT), an extracellular protein, might be involved in cardiac repair post myocardial infarction (MI). However, the specific impact of nephronectin during cardiac repair in MI remains elusive.
Topics & Concepts
AngiogenesisMedicineMyocardial infarctionSTAT3Cancer researchCardiac fibrosisFibrosisPhosphorylationCardiologyInternal medicineCell biologyBiologyCardiac Fibrosis and RemodelingCongenital heart defects researchSignaling Pathways in Disease