Transition metal-catalysis in interrupted borrowing hydrogen strategy
Madhu Nallagangula, Murugan Subaramanian, Rohit Kumar, Ekambaram Balaraman
Abstract
various C-C and C-heteroatom bond-forming reactions. The advantages of these approaches include (i) use of feedstock chemicals, (ii) high atom economy, (iii) no pre-activation of the substrates, and (iv) producing water as the only by-product. In this context, several synthetic strategies have been developed in this regime for the past few decades. To the best of our knowledge, no review article describes the important concepts of interrupted borrowing hydrogen (IBH) reaction. This review article highlights the recent advances in the IBH strategy and its application in sustainable chemical synthesis, particularly C-C bond formation using methanol as a C1 source, synthesis of 3,3'-bisindolylmethanes (3,3'-BIMs), α-branched ketones/diketones, and regioselective alkylation of N-heterocycles.