Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery
Graça Almeida‐Porada, Anthony Atala, Christopher D. Porada
Abstract
; (5) the efficiency with which they can be modified with viral-based vectors; and (6) their almost uncanny ability to selectively home to damaged tissues, tumors, and metastases following systemic administration. In this review, we summarize the latest research in the immunological properties of MSCs, their use as immunomodulatory/anti-inflammatory agents, methods for licensing MSCs to customize their immunological profile, and their use as vehicles for transferring both therapeutic genes in genetic disease and drugs and genes designed to destroy tumor cells.
Topics & Concepts
Mesenchymal stem cellImmunotherapyGene deliveryStromal cellDrug deliveryDrugGenetic enhancementCancer researchMedicineGenePharmacologyImmunologyBiologyChemistryImmune systemPathologyGeneticsOrganic chemistryMesenchymal stem cell researchRNA Interference and Gene DeliveryElectrospun Nanofibers in Biomedical Applications