Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans
Eric Delarze, Ludivine Brandt, Emilie Trachsel, Marion Patxot, Claire Pralong, Fabio Maranzano, Murielle Chauvel, Mélanie Legrand, Sadri Znaidi, Marie‐Elisabeth Bougnoux, Christophe d’Enfert, Dominique Sanglard
Abstract
in clinical FLC-tolerant strains consistently decreased their FLC tolerance. Transcription profiling of clinical isolates with variable levels of FLC tolerance confirmed a calcineurin-dependent signature in these isolates when exposed to FLC.
Topics & Concepts
Candida albicansCorpus albicansBiologyTranscription factorGeneGeneticsPhenotypeMicrobiologyAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatmentFungal Infections and Studies