Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor
Francesca Gado, Kawthar A. Mohamed, Serena Meini, Rebecca Ferrisi, Simone Bertini, Maria Digiacomo, Felicia D’Andrea, Lesley Stevenson, Robert B. Laprairie, Roger G. Pertwee, Clementina Manera
Topics & Concepts
ChemistryAllosteric regulationStereochemistryRadioligandCarboxamideMoietyAllosteric modulatorStructure–activity relationshipCannabinoid receptorCannabinoidAmideBinding siteIn vitroReceptorAgonistBiochemistryCannabis and Cannabinoid ResearchPharmacological Receptor Mechanisms and EffectsNeurotransmitter Receptor Influence on Behavior