Intestinal microbial communities and <i>Holdemanella</i> isolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5 <sup>+</sup> CD4 <sup>+</sup> T cells
Eiko Yamada, Casey Martin, Nancy Moreno-Huizar, Jennifer Fouquier, C. Preston Neff, Sara L. Coleman, Jennifer M. Schneider, Jonathan Huber, Nichole Nusbacher, Martin D. McCarter, Thomas Campbell, Catherine Lozupone, Brent E. Palmer
Abstract
isolates revealed unique cell wall and capsular components, which may be responsible for their differences in immunogenicity. These findings describe a novel mechanism potentially linking intestinal dysbiosis in MSM to HIV transmission and mucosal pathogenesis.
Topics & Concepts
BiologyLamina propriaMen who have sex with menImmunologyFecesMicrobiologyVirologyHuman immunodeficiency virus (HIV)GeneticsEpitheliumSyphilisGut microbiota and healthHIV Research and TreatmentHIV/AIDS Research and Interventions