Maintenance of neural stem cell positional identity by <i>mixed-lineage leukemia 1</i>
Ryan N. Delgado, Benjamin Mansky, Sajad Hamid Ahanger, Changqing Lu, Rebecca Andersen, Yali Dou, Arturo Álvarez-Buylla, Daniel A. Lim
Abstract
)-dependent epigenetic memory system. After establishment by sonic hedgehog, ventral NSC identity became independent of this morphogen. Even transient MLL1 inhibition caused a durable loss of ventral identity, resulting in the generation of neurons with the characteristics of dorsal NSCs in vivo. Thus, spatial information provided by morphogens can be transitioned to epigenetic mechanisms that maintain regionally distinct developmental programs in the forebrain.
Topics & Concepts
ForebrainMorphogenBiologyNeuroscienceSonic hedgehogNeural stem cellLineage (genetic)Neural tubeEpigeneticsStem cellCell biologyCentral nervous systemGeneticsEmbryoSignal transductionGeneEpigenetics and DNA MethylationNeurogenesis and neuroplasticity mechanismsGenomics and Chromatin Dynamics