Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale
Georg T. Höfler, Andrada But, Sabry H. H. Younes, Ron Wever, Caroline E. Paul, Isabel W. C. E. Arends, Frank Hollmann
Abstract
The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.
Topics & Concepts
Scale (ratio)ChemistryBiochemical engineeringCurrent (fluid)Identification (biology)SCALE-UPBiological systemCombinatorial chemistryChromatographyOrganic chemistryNanotechnologyMaterials scienceBiologyEngineeringPhysicsThermodynamicsEcologyQuantum mechanicsClassical mechanicsChemistry and Chemical EngineeringOxidative Organic Chemistry ReactionsVanadium and Halogenation Chemistry