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Squidiff: predicting cellular development and responses to perturbations using a diffusion model

Siyu He, Yuefei Zhu, Daniel Naveed Tavakol, Haotian Ye, Yeh‐Hsing Lao, Zixian Zhu, Cong Xu, Shradha Chauhan, Guy Garty, Raju Tomer, Gordana Vunjak‐Novakovic, James Zou, Elham Azizi, Kam W. Leong

2025Nature Methods19 citationsDOIOpen Access PDF

Topics & Concepts

TranscriptomeIn silicoRobustness (evolution)Computational biologyBiologyCell typeCellDrug developmentBiological systemSystems biologyComputer scienceCell growthFeature (linguistics)Cell biologyCell fate determinationGene expression profilingGene regulatory networkCellular stress responseNeuroscienceSingle-cell analysisDistinctive featureBioinformaticsSingle-cell and spatial transcriptomicsCell Image Analysis TechniquesGene Regulatory Network Analysis