Molecular Characterization of WCK 5222 (Cefepime/Zidebactam)-Resistant Mutants Developed from a Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate
Xiaolei Pan, Xinrui Zhao, Yuqin Song, Huan Ren, Zhenyang Tian, Liang Qian, Yongxin Jin, Fang Bai, Zhihui Cheng, Jie Feng, Weihui Wu
Abstract
passaging assay by using a multidrug-resistant P. aeruginosa clinical isolate. Our results revealed that mutations in the zidebactam target protein PBP2 play a major role in the bacterial resistance to WCK 5222. We further demonstrated that the mutations reduced the affinities between PBP2 and zidebactam and resulted in functional resistance of PBP2 to zidebactam.
Topics & Concepts
CefepimePseudomonas aeruginosaMicrobiologyCeftazidimeAntibioticsBiologyCefpiromeMultiple drug resistanceAntibiotic resistanceImipenemBacteriaGeneticsAntibiotic Resistance in BacteriaVibrio bacteria research studiesBacterial biofilms and quorum sensing