Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations
Rakshit S. Tanna, Dandan Tian, Nadja B. Cech, Nicholas H. Oberlies, Allan E. Rettie, Kenneth E. Thummel, Mary F. Paine
Topics & Concepts
DextromethorphanPharmacologyCYP3AChemistryCYP2D6AlkaloidDextrorphanMicrosomeCYP3A4PharmacokineticsMidazolamCYP2C9Indole alkaloidCYP1A2IC50Cytochrome P450BiochemistryStereochemistryBiologyMetabolismIn vitroSedationAlkaloids: synthesis and pharmacologyTraditional and Medicinal Uses of AnnonaceaeChemical synthesis and alkaloids