Solvent coordination to palladium can invert the selectivity of oxidative addition
Emily K. Elias, Steven M. Rehbein, Sharon R. Neufeldt
Abstract
In the presence of the bulky monophosphine P t Bu 3 , palladium usually prefers to react with Ar–Cl over Ar–OTf bonds. However, strongly coordinating solvents can bind to palladium, inducing a reversal of selectivity.
Topics & Concepts
SelectivityChemistryTrifluoromethanesulfonateCatalysisOxidative additionPalladiumSolventHalideSolvent effectsStoichiometryLigand (biochemistry)Transition statePhotochemistryCombinatorial chemistryInorganic chemistryOrganic chemistryReceptorBiochemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions