Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
Ines Stevic, Gustav Buescher, Franz Ricklefs
Abstract
Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communication and are worth being considered as biomarkers for both early diagnosis of cancer patients and real-time monitoring of treatment response. Recently, emerging evidence verified EVs to have crucial roles in cancer progression and metastasis and a great potential in therapeutic applications. In this review, we discuss the potential of EVs in monitoring the efficacy of cancer therapies.
Topics & Concepts
Extracellular vesiclesCancerVesicleMetastasisCancer cellCellExtracellular vesicleLipid bilayerCancer therapyBiologyCell biologyCancer researchMicrovesiclesBiochemistryMembranemicroRNAGeneticsGeneExtracellular vesicles in diseaseMicroRNA in disease regulationNanoplatforms for cancer theranostics