Molecular Characterization of Clinical Rel Mutations and Consequences for Resistance Expression and Fitness in Staphylococcus aureus
Ashley T. Deventer, Duncan Bryson, Mathew Shortill, A.B. Boraston, Joanne K. Hobbs
Abstract
The stringent response (SR) is a universal stress response that acts as a global regulator of bacterial physiology and virulence, and is a contributor to antibiotic tolerance and resistance. In most bacteria, the SR is controlled by a bifunctional enzyme, Rel, which both synthesizes and hydrolyzes the alarmone (p)ppGpp via two distinct catalytic domains.
Topics & Concepts
BiologyStringent responseAntibioticsMicrobiologyMultidrug toleranceMutantVirulenceBacteriaHydrolaseMutationGeneticsAntibiotic resistanceStaphylococcus aureusEnzymeBiochemistryGeneBiofilmAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaClostridium difficile and Clostridium perfringens research