Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
Alex G. Hamilton, Kelsey L. Swingle, Michael J. Mitchell
Abstract
The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.
Topics & Concepts
Nucleic acidBiologySolid lipid nanoparticleTranslation (biology)BiotechnologyNanotechnologyBiochemistryComputational biologyPharmacologyMaterials scienceMessenger RNAGeneDrugRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesVirus-based gene therapy research