Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity
Michel Goldman, Cédric Hermans
Abstract
Thrombotic thrombocytopenia mimicking heparin-induced thrombocytopenia has been observed in patients with severe Coronavirus Disease 2019 (COVID-19AU : Pleasenotethat COVID ) or after immunisation with adenoviral vector-based vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Herein, we discuss the pathogenesis of the autoimmune response to platelet factor 4 (PF4) that underlies these disorders.
Topics & Concepts
MedicineCoronavirus disease 2019 (COVID-19)VaccinationAutoimmunityImmunology2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PlateletAdverse effectVirologyInternal medicineImmune systemOutbreakInfectious disease (medical specialty)DiseaseHeparin-Induced Thrombocytopenia and ThrombosisPlatelet Disorders and TreatmentsBlood groups and transfusion