Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cells
Maria Giulia Manzione, Jan Rombouts, Mikhail Steklov, Lorenzo Pasquali, Anna Sablina, Lendert Gelens, Junbin Qian, Mathieu Bollen
Abstract
. The deregulation of these mechanisms can account for the balanced co-overexpression of Aurora B and RepoMan in many cancers, which limits chromosome segregation errors. In addition, Aurora B and RepoMan independently promote cancer cell proliferation by reducing checkpoint--induced cell-cycle arrest during interphase. The co-up-regulation of RepoMan and Aurora B in tumors is inversely correlated with patient survival, underscoring its potential importance for tumor progression. Finally, we demonstrate that high RepoMan levels sensitize cancer cells to Aurora-B inhibitors. Hence, the co-up-regulation of RepoMan and Aurora B is associated with tumor aggressiveness but also exposes a vulnerable target for therapeutic intervention.