Polymorph prediction through observed structural isomorphism leading to a new crystalline form of cannabidiol
Hannah E. Straker, Lynn McMillan, Lina Mardiana, Glen R. Hebberd, Elle Watson, Paul G. Waddell, Michael R. Probert, Michael J. Hall
Abstract
A new polymorph of cannabidiol (CBD, form 2), a bioactive phytocannabinoid, was discovered via high-throughput crystallisation. CBD form 2 fits within a series of crystal structures of CBD C-5′ homologues, forming a set of homologous isomorphs.
Topics & Concepts
CannabidiolIsomorphism (crystallography)StereochemistryCrystal structureChemistryCrystallographyCombinatorial chemistryMaterials scienceCannabisMedicinePsychiatryCannabis and Cannabinoid ResearchDiet, Metabolism, and DiseasePolyamine Metabolism and Applications